We believe Metabolomics will be valuable in guiding Precision Medicine, supporting not only those who are ill, but also those who want to make the most of their physical health and fitness. With the donation of less than 2 teaspoons of blood you can help in the development of a new tool for the future well-being of all.
Eric Gordon, MD
Founder and President of SISOH
WE NEED A LITTLE BIT OF YOUR BLOOD
Dear Parkpoint Members,
We need a little bit of your blood.
We need this to help us continue research into chronic and inflammatory illnesses.
This is research is being done in cooperation with:
Robert Naviaux MD PhD – Professor of Genetics, Biochemical Genetics and Metabolism
Departments of Medicine, Pediatrics, and Pathology
Co-director, The Mitochondrial and Metabolic Disease Center (MMDC)
University of California, San Diego (UCSD) School of Medicine
We need healthy people to help us define the role of Metabolomics in health and disease. Metabolomics is a new technique used to study the chemicals your body uses for energy, communication, and the construction of cell membranes. We are focusing on chronic illnesses involving immune dysfunction. Our first joint paper with Dr. Naviaux, a nationally acclaimed, published study on the biochemical characteristics of Chronic Fatigue Syndrome was published in Proceedings of the National Academy of Sciences in August 2016. A confirmatory study is being completed and will be published this Fall. Future studies will look at Lyme disease, Parkinson’s disease, dementia, and other conditions as funding becomes available. Our current research leads us to believe that Metabolomics testing will be valuable in diagnosing disease as well as in guiding treatment. We are currently recruiting patients and healthy controls for our third study.
Our research leads us to believe that Metabolomics testing will be valuable in diagnosing disease as well as in guiding treatment. The Metabolomics research utilizes a machine called tandem-Mass Spectroscopy, which measures hundreds of chemicals in one small sample of blood. The chemicals that we are measuring are called Metabolites. These include many of the hormones, fats and small proteins your body uses for energy metabolism, tissue repair, and maintenance, as well as cell to cell communication. The data from the Mass Spectrometer is specific for the individual chemical but the amount has to be inferred mathematically. In order to be sure our data is useful, we need to run large numbers of patient samples, and even larger numbers of controls to be sure the information is consistent and repeatable.
WHY DO WE NEED YOUR BLOOD?
At this time, we need to run each patient simultaneously with 15-20 age and sex matched controls (you will be a control). Using healthy people as controls allows us to differentiate ill people from healthy people. To be sure that our data is valid this process is repeated three times for each patient sample. We need to keep acquiring new control blood because stored blood changes over time even at minus 80 centigrade, the temperature at which we store the blood.
How much blood? Ten cc, which is about two teaspoons full. Not much to help science, is it?
WHAT’S IN IT FOR YOU?
With enough participants from Parkpoint we will also be able to measure the biochemistry of different levels of exercise. We believe Metabolomics will be valuable in guiding Precision Medicine, supporting not only those who are ill, but also those who want to make the most of their physical health and fitness. With the donation of less than 2 teaspoons of blood you can help in the development of a new tool for the future well-being of all.
Second, you will be helping people with many different hard to diagnose diseases have a chance at an earlier and more definite diagnosis. People with Chronic Fatigue, post Lyme syndrome, fibromyalgia, and even ALS can go a long time without a diagnosis. Being ill with no routine blood tests showing anything wrong is difficult for both patients and their doctors. Many previously high functioning, athletic people are told that they are depressed or malingering by well-meaning physicians because we lack clear cut diagnostic testing for these illnesses. The early stages of many common diseases, including autoimmune diseases, dementias, and cardiovascular disease also lack clear cut biochemical markers. Applying Metabolomics to these patient populations will change this, and give doctors the tools they need to help treat patients earlier.
HOW TO PARTICIPATE?
1.) Have your blood drawn.
Make an appointment to come in, at your convenience, to Gordon Medical. Our experienced phlebotomists can draw your blood quickly and easily.
Be sure you don’t eat or drink for at least 3 hours ahead of time!
Water is OK.
Kelly Fox, Research Coordinator
Gordon Medical is located at 3471 Regional Parkway, Santa Rosa, CA 95403
2.) You will be given a link to fill out a brief online survey.
SISOH Research Coordinator.